Advances in Protein Chemistry, Volume 12 (Anfinsen Jr., C. B.)

Advances in Protein Chemistry, Volume 65: Proteome Characterization and Proteomics

1 CombinatoRx, Incorporated, Cambridge, MA, USA, 2 Bioinformatics and Biomedical Engineering, Boston University, Boston, MA, USA and 3 Department of Biological Sciences and Department of Chemistry, Fairchild Center, Columbia University, New York, NY, USA * Corresponding author. CombinatoRx, Incorporated, 245 First St, Cambridge, MA 02142, USA. Tel.: þ 1 617 301 7151; Fax: þ 1 617 301 7110; E-ma...

Advances in Protein Chemistry

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Advances in Organometallic and Protein Chemistry

Organometallic chemistry of b(12) coenzymes.

When coenzyme B(12) was identified as organometallic derivative of vitamin B(12), metal-carbon bonds were revealed to be relevant in life processes. Vitamin B(12), the "antipernicious anaemia factor" required for human health, was isolated earlier as a crystallizable cyano-Co(III)-complex. B(12) cofactors and other cobalt corrinoids play important roles not only in humans, but in the metabolism...

Anfinsen: Amino Acid Sequence Determines Protein Shape

The hypothesis that “protein amino acid sequence determines the final shape a protein assumes in a water solution” was proven to be correct when Christian B. Anfinsen showed that if the enzyme ribonuclease was opened out into a linear chain and then allowed to reform, it reassumed the correct catalytic shape. This experiment is a critical one in the understanding of the nature of gene expressio...